Query: NC_015846:531984 Capnocytophaga canimorsus Cc5 chromosome, complete genome
Lineage: Capnocytophaga canimorsus; Capnocytophaga; Flavobacteriaceae; Flavobacteriales; Bacteroidetes; Bacteria
General Information: Capnocytophaga canimorsus is a commensal Gram-negative bacterium from the canine oral cavity that may cause severe zoonosis after dog bites. Capnocytophaga canimorsus is able to escape and modulate innate immunity at several levels and has the unusual property to feed on cultured mammalian cells, including phagocytes.
Subject: NC_010161:2050816 Bartonella tribocorum CIP 105476, complete genome
Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria
General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.