Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:2050816 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
205081620526811866type III restriction system methylaseQuickGO ontologyBLASTP
205269320556682976restriction enzyme of type III restriction-modification systemQuickGO ontologyBLASTP
2057335205741177tRNA-MetQuickGO ontology
205752320576411195S ribosomal RNAQuickGO ontologyBLASTP
20577022060281258023S ribosomal RNAQuickGO ontologyBLASTP
2060853206092876tRNA-AlaQuickGO ontologyBLASTP
2061250206132677tRNA-IleQuickGO ontology
20617982063291149416S ribosomal RNAQuickGO ontologyBLASTP
206411420661021989membrane protein related to metalloendopeptidasesQuickGO ontologyBLASTP
20672102067329120hypothetical proteinBLASTP
20680922068199108hypothetical proteinBLASTP
206852820699851458hypothetical proteinBLASTP
20701772070731555RNA polymerase sigma factorQuickGO ontologyBLASTP
20707392070942204hypothetical proteinBLASTP
20711092071903795two-component response regulatorQuickGO ontologyBLASTP
207192620729391014two-component system sensor histidine kinaseQuickGO ontologyBLASTP