Query: NC_015683:2469481 Corynebacterium ulcerans BR-AD22 chromosome, complete genome
Lineage: Corynebacterium ulcerans; Corynebacterium; Corynebacteriaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: They may be found as members of the normal microflora of humans, where these bacteria find a suitable niche in virtually every anatomic site. Corynebacterium ulcerans is commonly associated with dairy animals and unpasturized dairy products. This organism has been implicated in bovine mastitis and can cause skin infections and a diptheria-like disease in humans.
Subject: NC_008767:1888950 Neisseria meningitidis FAM18, complete genome
Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria
General Information: Isolated from a patient with meningococcal septicemia. Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.