Query: NC_015573:3070582 Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genome
Lineage: Desulfotomaculum kuznetsovii; Desulfotomaculum; Peptococcaceae; Clostridiales; Firmicutes; Bacteria
General Information: Country: Georgia; Environment: Animal intestinal microflora, Fresh water; Isolation: underground thermal mineral water; Temp: Mesophile; Temp: 60C. Desulfotomaculum kuznetsovii is a thermophilic spore-forming bacterium which can grow using sulfate as an electron acceptor. This organism is isolate from hot springs and oil field samples.
Subject: NC_005956:699206 Bartonella henselae str. Houston-1, complete genome
Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria
General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.