Query: NC_014562:1698253 Pantoea vagans C9-1 chromosome, complete genome Lineage: Pantoea vagans; Pantoea; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: Pantoea vagans (strain C9-1) is a Gram-negative enterobacterial plant epiphyte isolated from apple. Strains belonging to this species have been isolated from eucalyptus leaves showing symptoms of bacterial blight and die-back in Uganda, Uruguay and Argentina and from maize suffering from brown stalk rot in South Africa.
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General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.