Pre_GI Gene

Some Help

Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:1737885 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17389851739347363hypothetical proteinBLASTP
17395751740228654formate dehydrogenase-N nitrate-inducible cytochrome B556Fdn gamma subunitQuickGO ontologyBLASTP
17402211741105885formate dehydrogenase-N nitrate-inducible iron-sulfur beta subunitQuickGO ontologyBLASTP
174111817441653048formate dehydrogenase-N nitrate-inducible alpha subunitQuickGO ontologyBLASTP
17443971745278882hypothetical proteinBLASTP
174553717466371101putative outer membrane porin proteinQuickGO ontologyBLASTP
174680717479701164hypothetical proteinBLASTP
174805417490851032IS630 ORFQuickGO ontologyBLASTP
17503861751225840IS2 ORF2QuickGO ontologyBLASTP
175157117529321362nitrite extrusion protein 2QuickGO ontologyBLASTP
175301417567543741cryptic nitrate reductase 2 alpha subunitQuickGO ontologyBLASTP
175675117582951545cryptic nitrate reductase 2 beta subunitQuickGO ontologyBLASTP
17582951758990696cryptic nitrate reductase 2 delta subunit assembly functionQuickGO ontologyBLASTP
17589871759667681cryptic nitrate reductase 2 gamma subunitQuickGO ontologyBLASTP
17597461760639894hypothetical proteinBLASTP