Query: NC_013946:2854219 Meiothermus ruber DSM 1279 chromosome, complete genome
Lineage: Meiothermus ruber; Meiothermus; Thermaceae; Thermales; Deinococcus-Thermus; Bacteria
General Information: Isolation: Hot spring; Temp: Thermophile; Temp: 50 - 60C; This organism is a pigmented thermophilic bacterium which can be found in hot springs. Thermophilic, aerobic, non-motile, free-living, Gram-negative.
Subject: NC_007797:914500 Anaplasma phagocytophilum HZ, complete genome
Lineage: Anaplasma phagocytophilum; Anaplasma; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria
General Information: Isolated from a patient in New York, USA, in 1995. This organism is a tick-borne (Ixodesspp.) obligate intracellular pathogen that infects humans and causes human granulocytic anaplasmosis as well as infecting several other types of animals. This organism produces a number of pathogenic factors that aid virulence. These include specific adhesins for neutrophils, virulence factors that inhibit both phagosome-lysozome fusion and production of reactive oxygen species that would normally kill the bacterium. The bacterium also inhibits programmed cell death of the neutrophil (apoptosis) and induces expression of interleukin-8, which causes neutrophil chemotaxis, thereby increasing the spread of the bacterium throughout the host organism.