Query: NC_013174:2712000 Jonesia denitrificans DSM 20603, complete genome
Lineage: Jonesia denitrificans; Jonesia; Jonesiaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: Isolation: Boiled ox blood; Temp: Mesophile; Temp: 37C. This species was formerly classified as Listeria denitrificans, and is the only species of the genus Jonesia. It is a Gram-positive nonspore-forming, motile rod that is catalase positive, oxidase negative, and facultatively anaerobic.
Subject: NC_011896:491052 Mycobacterium leprae Br4923, complete genome
Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.