Pre_GI Gene

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Host: NC_011896 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011896:491052 Mycobacterium leprae Br4923, complete genome

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4910524926411590putative GMP synthaseQuickGO ontologyBLASTP
4927234938321110hypothetical proteinBLASTP
4939484957561809putative transporter proteinQuickGO ontologyBLASTP
4960694971061038putative D-ribose-binding proteinQuickGO ontologyBLASTP
5032265044101185hypothetical proteinBLASTP
504468504788321hypothetical proteinBLASTP
504802505452651hypothetical proteinBLASTP
508336508638303putative PE-family proteinQuickGO ontologyBLASTP
5087645099901227serine-rich antigenQuickGO ontologyBLASTP