Query: NC_012483:3731542 Acidobacterium capsulatum ATCC 51196, complete genome Lineage: Acidobacterium capsulatum; Acidobacterium; Acidobacteriaceae; Acidobacteriales; Acidobacteria; Bacteria General Information: Isolated from acidic mine drainage in Yanahara mine, Okayama, Japan. Acidophilic bacterium. This genus comprises a number of species commonly found in water reservoirs, microbial mats, many different soil types, marine and freshwater sediments, as well as in hot-spring mats and sediments, etc. Furthermore, they sometimes form the dominant group in a habitat. These bacteria are involved in the first step of destruction of biologically complex molecules produced by autotrophic (capable of synthesizing their own nutrients) microorganisms. Acidobacterium capsulatum is an aerobic, mesophilic, chemo-organotroph able to use a variety of carbon sources and to grow up to pH 6.0. The species comprises several strains characterized by orange pigmentation, production of menoquinones as their sole quinones, and branched-chain iso fatty acids as their cell envelope components.
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General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.