Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:1844452 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
184445218462841833type III restriction system methylaseQuickGO ontologyBLASTP
184629618492712976restriction enzyme of type III restriction-modification systemQuickGO ontologyBLASTP
1850938185101477tRNA-MetQuickGO ontology
185112618512441195S ribosomal RNAQuickGO ontologyBLASTP
18513051853929262523S ribosomal RNAQuickGO ontologyBLASTP
1854456185453176tRNA-AlaQuickGO ontologyBLASTP
1854853185492977tRNA-IleQuickGO ontology
18554011856894149416S ribosomal RNAQuickGO ontologyBLASTP
18576841858076393FUR family transcriptional regulatorQuickGO ontologyBLASTP
185823218593261095multidrug resistance efflux pump VceA proteinQuickGO ontologyBLASTP
185935118609221572multidrug resistance protein VceBQuickGO ontologyBLASTP
18638051864389585hypothetical proteinBLASTP
186446718656001134lysineornithine decarboxylaseQuickGO ontologyBLASTP