Query: NC_012108:5273289 Desulfobacterium autotrophicum HRM2, complete genome
Lineage: Desulfobacterium autotrophicum; Desulfobacterium; Desulfobacteraceae; Desulfobacterales; Proteobacteria; Bacteria
General Information: It was isolated from a marine sediment in the Mediterranean sea near Venice, Italy. It is involved in the anaerobic mineralization of organic matter coming from the water column. Desulfobacterium autotrophicum is capable of growing litho-autotrophically with H2, CO2 and sulfate, but also by coupling sulfate reduction with the oxidation of fatty acids. This organism can transform tetra to dichlormethane.
Subject: NC_004557:32094 Clostridium tetani E88, complete genome
Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria
General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.