Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:32094 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
32094343102217sensor histidine kinaseQuickGO ontologyBLASTP
34405370682664hypothetical proteinBLASTP
3711137623513transcriptional regulatorQuickGO ontologyBLASTP
3764138144504hypothetical proteinBLASTP
382513832676tRNA-AlaQuickGO ontologyBLASTP
383323840877tRNA-MetQuickGO ontologyBLASTP
3842638513885S ribosomal RNAQuickGO ontologyBLASTP
3869241536284523S ribosomal RNAQuickGO ontologyBLASTP
3902439680657hypothetical proteinBLASTP
4180143309150916S ribosomal RNAQuickGO ontologyBLASTP
43745461862442DNA gyrase subunit AQuickGO ontologyBLASTP
46198481111914DNA gyrase subunit BQuickGO ontologyBLASTP
48425495371113recombination protein FQuickGO ontologyBLASTP
49861509641104DNA polymerase III subunit betaQuickGO ontologyBLASTP
51225522531029chromosomal replication initiation proteinQuickGO ontologyBLASTP
5383654498663putative inner membrane protein translocase component YidCQuickGO ontologyBLASTP
5449155138648conserved protein JAG-familyQuickGO ontologyBLASTP
55193565721380tRNA modification GTPaseQuickGO ontologyBLASTP