Pre_GI: SWBIT SVG BLASTN

Query: NC_009488:327285 Orientia tsutsugamushi str. Boryong, complete genome

Lineage: Orientia tsutsugamushi; Orientia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from a human in 1995 in Boryong, Korea. Causal agent of scrub typhus. This organism is the causative agent of scrub typhus, and like other members of the Rickettsiales is an obligate intracellular organism. Scrub typhus, which occurs in rural and agricultural areas, is one of the most common infectious diseases in southeast Asia where an estimated 1 million cases occur each year. Many cases are mild, but if left untreated, a variety of serious illnesses can arise and fatality rates can range from 1-35%. Transmission occurs via an insect vector through the bite of the larval trombiculid mite (chiggers). The bacterium is transmitted transovarially in mites (from females to their offspring).

Subject: NC_012808:806432 Methylobacterium extorquens AM1, complete genome

Lineage: Methylobacterium extorquens; Methylobacterium; Methylobacteriaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: First isolated in 1960 in Oxford, England, as an airborne contaminant growing on methylamine. This strain can grow on methylamine or methanol, but not methane. This organism is capable of growth on one-carbon compounds such as methanol. Methanol is oxidized to formaldehyde which is then used metabolically to generate either energy or biomass. These bacteria are commonly found in the environment, especially associated with plants which produce methanol when metabolizing pectin during cell wall synthesis. At least 25 genes are required for this complex process of converting methanol to formaldehyde and this specialized metabolic pathway is of great interest.