Pre_GI: SWBIT SVG BLASTN

Query: NC_008149:587689 Yersinia pestis Nepal516, complete genome

Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

Subject: NC_011071:4000620 Stenotrophomonas maltophilia R551-3, complete genome

Lineage: Stenotrophomonas maltophilia; Stenotrophomonas; Xanthomonadaceae; Xanthomonadales; Proteobacteria; Bacteria

General Information: Stenotrophomonas maltophilia R551-3 was isolated from the poplar Populus trichocarpa x deltoides cv. "Hoogvorst" and is the second most common endophytic bacteria in poplar. Endophytic bacteria have been shown to increase plant growth or health but providing growth factors or nutrients and in aiding the degradation of toxic compounds. This species is an uncommon but serious source of infection in patients with breathing tubes such as endotracheal or tracheostomy tubes, or with chronically indwelling urinary catheters. Although the organism can colonize the devices without causing an infection, under certain conditions it can cause pneumonia, urinary tract infections, or an infection of the blood. This organism can also cause infection in immunocompromised patients. It has resistance to many commonly used antibiotics and therefore is often difficult to eradicate. Most strains are resistant to co-trimoxazole.