Query: NC_007798:652317 Neorickettsia sennetsu str. Miyayama, complete genome
Lineage: Neorickettsia sennetsu; Neorickettsia; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria
General Information: This organism was first described in 1953 in Japan as causing Sennetsu fever. Causes an infectious mononucleosis-like disease. Like other Ehrlichia, this organism is an obligate intracellular pathogen. It can be transmitted from fish flukes (trematodes) to humans, and was one of the first Ehrlichia that was found to cause a human-specific illness.
Subject: NC_007797:1451804 Anaplasma phagocytophilum HZ, complete genome
Lineage: Anaplasma phagocytophilum; Anaplasma; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria
General Information: Isolated from a patient in New York, USA, in 1995. This organism is a tick-borne (Ixodesspp.) obligate intracellular pathogen that infects humans and causes human granulocytic anaplasmosis as well as infecting several other types of animals. This organism produces a number of pathogenic factors that aid virulence. These include specific adhesins for neutrophils, virulence factors that inhibit both phagosome-lysozome fusion and production of reactive oxygen species that would normally kill the bacterium. The bacterium also inhibits programmed cell death of the neutrophil (apoptosis) and induces expression of interleukin-8, which causes neutrophil chemotaxis, thereby increasing the spread of the bacterium throughout the host organism.