Query: NC_007794:262402 Novosphingobium aromaticivorans DSM 12444, complete genome Lineage: Novosphingobium aromaticivorans; Novosphingobium; Sphingomonadaceae; Sphingomonadales; Proteobacteria; Bacteria General Information: This strain, also known as F199, was isolated from a sample obtained at a depth of 410 m from a borehole sample that was drilled at the Savannah River Site in South Carolina, USA. Aromatic hydrocarbon-degrading bacterium. This organism is unusual in that it has glycosphingolipid in the cell envelope instead of the lipopolysaccharide found in most other gram negative organisms. It is typically isolated from a wide range of environmental sites.
- Sequence; - BLASTN hit (Low score = Light, High score = Dark) - hypothetical protein; - cds: hover for description
General Information: Isolated from a patient in New York, USA, in 1995. This organism is a tick-borne (Ixodesspp.) obligate intracellular pathogen that infects humans and causes human granulocytic anaplasmosis as well as infecting several other types of animals. This organism produces a number of pathogenic factors that aid virulence. These include specific adhesins for neutrophils, virulence factors that inhibit both phagosome-lysozome fusion and production of reactive oxygen species that would normally kill the bacterium. The bacterium also inhibits programmed cell death of the neutrophil (apoptosis) and induces expression of interleukin-8, which causes neutrophil chemotaxis, thereby increasing the spread of the bacterium throughout the host organism.