Query: NC_007498:3655304 Pelobacter carbinolicus DSM 2380, complete genome Lineage: Pelobacter carbinolicus; Pelobacter; Pelobacteraceae; Desulfuromonadales; Proteobacteria; Bacteria General Information: Pelobacter carbinolicus DSM 2380 was isolated from mud in Venice, Italy. Iron- and sulfur-reducing bacterium. Pelobacter carbinolicus is commonly isolated from marine and freshwater sediments, and sewage sludge. This organism can make up a significant portion of the anaerobic microbial community in these environments. Pelobacter carbinolicus is also able to grow using iron and sulfur as terminal electron acceptors. This organism is closely related to the sulfur-reducing Desulfuromonas spp. and iron-reducing Geobacter spp..
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General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.