Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:3359598 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
33595983360224627hypothetical proteinBLASTP
33602003360403204hypothetical protein
33603963361289894ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
33613223362047726transcriptional regulator TetR familyQuickGO ontologyBLASTP
336207133631021032oxidoreductase GfoIdhMocA familyQuickGO ontologyBLASTP
336327233656952424DNA topoisomerase IV subunit AQuickGO ontologyBLASTP
336569733676611965DNA topoisomerase IV subunit BQuickGO ontologyBLASTP
33680373368450414CoA binding domain family proteinQuickGO ontologyBLASTP
336853033697711242serine proteaseQuickGO ontologyBLASTP
33699743370651678DNA-binding response regulatorQuickGO ontologyBLASTP
33708233371122300adical activatingQuickGO ontologyBLASTP
337111933729751857anaerobic ribonucleoside triphosphate reductaseQuickGO ontologyBLASTP
33732013373797597hypothetical proteinBLASTP
33739063374196291hypothetical proteinBLASTP
337422333746424204-hydroxybenzoyl-CoA thioesterase putativeQuickGO ontologyBLASTP
337475233760441293glycosyl hydrolase family 18QuickGO ontologyBLASTP
33760733376270198small acid-soluble spore protein TlpQuickGO ontology
33768333377780948DNA polymerase III subunit epsilonQuickGO ontologyBLASTP
33778963378471576ahpCTSA family proteinQuickGO ontologyBLASTP