Query: NC_004663:4977635 Bacteroides thetaiotaomicron VPI-5482, complete genome Lineage: Bacteroides thetaiotaomicron; Bacteroides; Bacteroidaceae; Bacteroidales; Bacteroidetes; Bacteria General Information: This is the type strain for this organism and was isolated from the feces of a healthy adult. Common gastrointestinal bacterium. This group of microbes constitute the most abundant members of the intestinal microflora of mammals. Typically they are symbionts, but they can become opportunistic pathogens in the peritoneal (intra-abdominal) cavity. Breakdown of complex plant polysaccharides such as cellulose and hemicellulose and host-derived polysaccharides such as mucopolysaccharides is aided by the many enzymes these organisms produce. Bacteroides thetaiotaomicron is one of the two major Bacteroidesspecies found in the intestine. This organism has been used in studies on gut microflora composition and succession.
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General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.