Query: NC_000868:196015 Pyrococcus abyssi GE5, complete genome Lineage: Pyrococcus abyssi; Pyrococcus; Thermococcaceae; Thermococcales; Euryarchaeota; Archaea General Information: This organism was isolated from an active chimney in the North Fiji Basin of the Pacific Ocean at a depth of 3500 meters. This organism is an obligate anaerobic, hyperthermophilic archaeon. Growth occurs at a temperature of 67-103 degrees C with optimal growth at 103 degrees C at 200 atmospheres of pressure. Increased hydrostatic pressure has been found to extend the upper growth temperature and stimulate growth.
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General Information: This strain was isolated from a patient in 1994. Opportunistic pathogen that causes multiple hospital-acquired infections. This organism is the most medically important organism within the genus Klebsiella. It is an environmental organism found in water, soil, and on the surface of plants. Several strains have been isolated from plant tissues and are nitrogen-fixing endophytes that may be a source of nitrogen for the plant. Other strains can become opportunistic pathogens which infect humans, and typically causes hospital-acquired infections in immunocompromised patients. Major sites of infection include the lungs, where it causes a type of pneumonia, and urinary tract infections. Klebsiella can also enter the bloodstream (bacterimia) and cause sepsis. The pathogen can also infect animals and cause inflammation of the uterus in horses as well as more generalized infections in other mammals. This organism expresses numerous pathogenicity factors, including multiple adhesins, capsular polysaccharide, siderophores, and lipopolysaccharide for the evasion of host defenses. The multiple antibiotic resistance genes carried on the chromosome inhibit efforts to clear the organism from infected patients via antibiotic use.