Query: NC_007608:97092 Shigella boydii Sb227 plasmid pSB4_227, complete sequence
D: 36.3239
Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria
General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.
Number of Neighbours: 17
Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!
Subject Island | Subject Host Description |
Compositional Similarity |
Proposed Island Flow | Subject Island D |
---|
NC_003277:22257 | Salmonella typhimurium LT2 plasmid pSLT, complete sequence | 79.038 % | Subject ←→ Query | 31.1132 |
NC_008563:3119284 | Escherichia coli APEC O1, complete genome | 78.4252 % | Subject ←→ Query | 31.9127 |
CU928160:256932 | Escherichia coli IAI1 chromosome, complete genome | 75.6005 % | Subject ←→ Query | 34.5956 |
NC_009801:3374501* | Escherichia coli E24377A, complete genome | 83.606 % | Subject ←→ Query | 36.3653 |
NC_004431:1352906 | Escherichia coli CFT073, complete genome | 78.8113 % | Subject ←→ Query | 36.4239 |
NC_002695:2158314 | Escherichia coli O157:H7 str. Sakai, complete genome | 77.1415 % | Subject ←→ Query | 36.4725 |
AP010958:1472506 | Escherichia coli O103:H2 str. 12009 DNA, complete genome | 80.7782 % | Subject ←→ Query | 36.7127 |
NC_011751:1377457 | Escherichia coli UMN026 chromosome, complete genome | 78.5539 % | Subject ←→ Query | 36.813 |
NC_010660:33109 | Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence | 75.1103 % | Subject ←→ Query | 36.8677 |
NC_002695:2893951 | Escherichia coli O157:H7 str. Sakai, complete genome | 76.9792 % | Subject ←→ Query | 37.275 |
NC_009648:3476000 | Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genome | 75.9835 % | Subject ←→ Query | 37.4593 |
NC_011750:1931384 | Escherichia coli IAI39 chromosome, complete genome | 76.7708 % | Subject ←→ Query | 37.6581 |
NC_007385:157516 | Shigella sonnei Ss046 plasmid pSS_046, complete sequence | 84.617 % | Subject ←→ Query | 38.0958 |
NC_002655:1909139 | Escherichia coli O157:H7 EDL933, complete genome | 79.087 % | Subject ←→ Query | 38.4667 |
NC_011750:919953 | Escherichia coli IAI39 chromosome, complete genome | 77.1446 % | Subject ←→ Query | 38.6045 |
NC_011750:2009889 | Escherichia coli IAI39 chromosome, complete genome | 75.242 % | Subject ←→ Query | 39.0625 |
NC_010660:175200* | Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence | 93.5999 % | Subject ← Query | 46.3542 |