n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)
n0_4mer:D = Distance between local and global OU patterns
n0_4mer:PS = Distance between 2 strands of same DNA molecule
Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS
NC_010168: Renibacterium salmoninarum ATCC 33209 chromosome, complete genome
NCBI: NC_010168
Host Lineage: Renibacterium salmoninarum; Renibacterium; Micrococcaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: This bacterial pathogen is the causal agent of bacterial kidney disease (BKD) of salmonid fish. This disease is a significant threat to the healthy and sustainable production of salmon for consumption and species conservation efforts in the USA. The development of treatments are further complicated as the organism is vertically transmitted from infected females to their eggs, is difficult to culture in vitro, and is a facultative intracellular pathogen. The completion of the genome sequence of Renibacterium salmoninarum will be a benefit to the scientific community at many levels and will be of immediate use to researchers and fish health practitioners dealing with BKD in farmed fish as well as captive broodstocks of endangered species-listed populations. For example, genome data will serve as a foundation for identification of virulence factors, DNA vaccine gene candidates, and improved diagnostic tests.