Pre_GI Gene

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Host: NC_017379 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017379:1233482 Helicobacter pylori Puno135 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12334821234186705purine-nucleoside phosphorylaseQuickGO ontologyBLASTP
123418312354241242phosphopentomutaseQuickGO ontologyBLASTP
123543612366921257pyrimidine nucleoside transport protein nupCQuickGO ontologyBLASTP
123701812383491332multidrug-efflux transporterQuickGO ontologyBLASTP
12383671239128762hypothetical proteinBLASTP
123913812402891152NaH antiporterQuickGO ontologyBLASTP
124031512416941380hypothetical proteinBLASTP
124185412430291176putative arabinose transporterQuickGO ontologyBLASTP
12433061244049744alpha-carbonic anhydraseQuickGO ontologyBLASTP
124433912461441806hypothetical proteinBLASTP
124621212479721761hypothetical proteinBLASTP
124815612491961041aspartate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
124918312505111329histidyl-tRNA synthetaseQuickGO ontologyBLASTP
125057312516221050ADP-heptose--LPS heptosyltransferase IIQuickGO ontologyBLASTP
12517561251974219hypothetical proteinBLASTP
12521921253181990aldo-ketoreductase putativeQuickGO ontologyBLASTP
125370312557812079elongation factor GQuickGO ontologyBLASTP
1255793125626046830S ribosomal protein S7QuickGO ontologyBLASTP