Pre_GI Gene

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Host: NC_017368 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017368:468934 Helicobacter pylori F16, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4689344707331800hypothetical proteinBLASTP
470749470904156Type II adenine specific DNA methyltransferaseQuickGO ontology
470905471420516Type II adenine specific DNA methyltransferaseQuickGO ontology
471534472022489IS605 transposaseQuickGO ontologyBLASTP
471964472617654hypothetical proteinBLASTP
4726944761823489hypothetical proteinBLASTP
4762484779181671hypothetical proteinBLASTP
4778814794911611DNA primaseQuickGO ontologyBLASTP
4794884806601173hypothetical proteinBLASTP
480673481125453hypothetical proteinBLASTP
481135481638504hypothetical proteinBLASTP
481655482125471hypothetical proteinBLASTP
482109482420312hypothetical proteinBLASTP
482423482644222hypothetical proteinBLASTP
482641482757117phage integraseQuickGO ontologyBLASTP
482826483788963putative phage integrase proteinQuickGO ontologyBLASTP
483785483907123hypothetical proteinBLASTP
483897484208312hypothetical proteinBLASTP
484441484647207Type II restriction endonucleaseQuickGO ontology
484883485827945catalase-like proteinQuickGO ontologyBLASTP
4861164877021587outer membrane protein HofCQuickGO ontologyBLASTP
4877754891721398outer membrane protein HofDQuickGO ontologyBLASTP