Pre_GI Gene

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Host: NC_017365 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017365:77150 Helicobacter pylori F30, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
76137771531017cation efflux system proteinQuickGO ontologyBLASTP
77150783881239outer membrane protein HefGQuickGO ontologyBLASTP
7839378770378hypothetical proteinBLASTP
78945803361392fumarate hydrataseQuickGO ontologyBLASTP
8035980610252hypothetical proteinBLASTP
8064181255615ribonuclease HIIQuickGO ontologyBLASTP
8122981816588hypothetical proteinBLASTP
82038831651128ATP-binding proteinQuickGO ontologyBLASTP
833318364531530S ribosomal protein S10QuickGO ontologyBLASTP
836828425757650S ribosomal protein L3QuickGO ontologyBLASTP
842928493964850S ribosomal protein L4QuickGO ontologyBLASTP
849438522428250S ribosomal protein L23QuickGO ontologyBLASTP
852408607083150S ribosomal protein L2QuickGO ontologyBLASTP
860828636328230S ribosomal protein S19QuickGO ontologyBLASTP
863738674136950S ribosomal protein L22QuickGO ontologyBLASTP
867458744970530S ribosomal protein S3QuickGO ontologyBLASTP
874528787742650S ribosomal protein L16QuickGO ontologyBLASTP
878648806420150S ribosomal protein L29QuickGO ontologyBLASTP
880788833826130S ribosomal protein S17QuickGO ontologyBLASTP
883418870936950S ribosomal protein L14QuickGO ontologyBLASTP
887098893022250S ribosomal protein L24QuickGO ontologyBLASTP
889438948854650S ribosomal protein L5QuickGO ontologyBLASTP
894988968318630S ribosomal protein S14QuickGO ontologyBLASTP
896939008839630S ribosomal protein S8QuickGO ontologyBLASTP
900999063553750S ribosomal protein L6QuickGO ontologyBLASTP
906499100535750S ribosomal protein L18QuickGO ontologyBLASTP
910209146344430S ribosomal protein S5QuickGO ontologyBLASTP
914819188240250S ribosomal protein L15QuickGO ontologyBLASTP
91920931821263preprotein translocase subunit SecYQuickGO ontologyBLASTP
9318293943762methionine aminopeptidaseQuickGO ontologyBLASTP
9394394161219translation initiation factor IF-1QuickGO ontologyBLASTP
9424094353114hypothetical protein
943579471936330S ribosomal protein S13QuickGO ontologyBLASTP
947429513739630S ribosomal protein S11QuickGO ontologyBLASTP
951479577362730S ribosomal protein S4QuickGO ontologyBLASTP
95785968191035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
968199716935150S ribosomal protein L17QuickGO ontologyBLASTP
9772998343615hypothetical proteinBLASTP
9833198993663nicotinamide mononucleotide transporterQuickGO ontologyBLASTP
9911599771657putative transcriptional regulatorQuickGO ontologyBLASTP