Pre_GI Gene

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Host: NC_017358 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017358:563336 Helicobacter pylori Cuz20 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5633365647811446cag pathogenicity island protein cag delta cag3QuickGO ontologyBLASTP
564791565300510cag pathogenicity island protein cag4QuickGO ontologyBLASTP
5654325676782247cag pathogenicity island protein cag beta cag5QuickGO ontologyBLASTP
567687568679993cag pathogenicity island protein cag alphaQuickGO ontologyBLASTP
568684569283600cag pathogenicity island protein cagZ cag6QuickGO ontologyBLASTP
569296569430135hypothetical proteinBLASTP
5694205718042385cag pathogenicity island protein cagY cag7QuickGO ontologyBLASTP
5745045760721569cag pathogenicity island protein cagX cag8QuickGO ontologyBLASTP
5761255777321608cag pathogenicity island protein cagW cag9QuickGO ontologyBLASTP
577737578495759cag pathogenicity island protein VQuickGO ontologyBLASTP
578771579418648cag pathogenicity island protein cagU cag11QuickGO ontologyBLASTP
579434580276843CAG pathogenicity island protein 12QuickGO ontologyBLASTP
580478581077600CAG pathogenicity island protein 13QuickGO ontologyBLASTP
581511581723213hypothetical proteinBLASTP
581783581962180hypothetical proteinBLASTP
581991582296306cag pathogenicity island protein cagQ cag14QuickGO ontologyBLASTP
58284958294496hypothetical proteinBLASTP
5840335851631131cag pathogenicity island protein cagM cag16QuickGO ontologyBLASTP