Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:3655876 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
36558763656769894DNA utilization protein YhiRQuickGO ontologyBLASTP
365684136581931353Glutathione oxidoreductaseQuickGO ontologyBLASTP
36583583658531174hypothetical proteinBLASTP
36591063659609504IS1 orfBQuickGO ontologyBLASTP
36597233660127405putative alpha-mannosidaseQuickGO ontologyBLASTP
36599593660384426Arsenate reductaseQuickGO ontologyBLASTP
366039736617071311putative NaH antiporter NhaD-like arsenite permeaseQuickGO ontologyBLASTP
36620503662259210IS150 ORF1QuickGO ontologyBLASTP
36623343662837504IS1 orfBQuickGO ontologyBLASTP
36628623663824963putative membrane transport proteinQuickGO ontologyBLASTP
366440536656281224hypothetical proteinBLASTP
36657103666441732Outer membrane protein induced after carbon starvationQuickGO ontologyBLASTP
36665973667127531HTH-type transcriptional regulator dctRQuickGO ontologyBLASTP
36678793668217339acid-resistance proteinQuickGO ontologyBLASTP
36683213668653333Hns-dependent expression protein HdeAQuickGO ontologyBLASTP
36689083669480573acid-resistance membrane proteinQuickGO ontologyBLASTP
36702793670806528Transcriptional regulator gadEQuickGO ontologyBLASTP
36711453672062918Multidrug resistance protein mdtE precursorQuickGO ontologyBLASTP
36722033672706504IS1 ORF2QuickGO ontologyBLASTP
36728203672960141IS600 ORF2QuickGO ontologyBLASTP
367317136748201650Cytoplasmic trehalaseQuickGO ontologyBLASTP
367494736762931347IS4 ORFQuickGO ontologyBLASTP
36763093676911603putative HTH-type transcriptional regulator yhjBQuickGO ontologyBLASTP
36773593678330972putative transcriptional regulator LYSR-typeQuickGO ontologyBLASTP
367837936793921014hypothetical proteinBLASTP