Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:751078 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7510787532252148formate dehydrogenase HQuickGO ontologyBLASTP
7532487538055584Fe-4S ferredoxinQuickGO ontologyBLASTP
7538287558432016putative oxidoreductase Fe-S binding subunitQuickGO ontologyBLASTP
756263756838576putative transcriptional regulatorQuickGO ontologyBLASTP
75698375705876tRNA-PheQuickGO ontologyBLASTP
7574927600472556enhancing factorQuickGO ontologyBLASTP
760077760244168hypothetical proteinBLASTP
760474760899426subtilase cytotoxin subunit B-like proteinQuickGO ontologyBLASTP
760962761264303transposaseQuickGO ontologyBLASTP
76149276158493hypothetical protein
7617557627891035rhamnose-proton symporterQuickGO ontologyBLASTP
762938763810873transcriptional activator RhaRQuickGO ontologyBLASTP
763943764764822transcriptional activator RhaSQuickGO ontologyBLASTP
764986765192207hypothetical proteinBLASTP
7651917666481458rhamnulokinaseQuickGO ontologyBLASTP
7666457679011257L-rhamnose isomeraseQuickGO ontologyBLASTP
767914768738825rhamnulose-1-phosphate aldolaseQuickGO ontologyBLASTP
7688057699531149alcohol dehydrogenaseQuickGO ontologyBLASTP
769967770281315L-rhamnose 1-epimeraseQuickGO ontologyBLASTP
770528771076549single-stranded DNA-binding proteinQuickGO ontologyBLASTP
7715347743772844excinuclease ABC subunit AQuickGO ontologyBLASTP