Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:341233 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3412333423121080iron-enterobactin transporter periplasmic binding proteinQuickGO ontologyBLASTP
3425243436301107Fimbrial proteinQuickGO ontologyBLASTP
343655344374720fimbrial chaperone proteinQuickGO ontologyBLASTP
3443923468722481outer membrane usher proteinQuickGO ontologyBLASTP
347225347683459IS1541 transposaseQuickGO ontologyBLASTP
347673347828156invasinQuickGO ontologyBLASTP
347935348393459transposaseQuickGO ontologyBLASTP
348593349015423hypothetical proteinBLASTP
349067349933867hypothetical proteinBLASTP
349930350784855pilus assembly protein CpaCQuickGO ontologyBLASTP
350799351248450type II and III secretion system proteinQuickGO ontologyBLASTP
351245351535291hypothetical proteinBLASTP
3515463526731128pilus assembly protein CpaEQuickGO ontologyBLASTP
3526853539711287putative type II secretion proteinQuickGO ontologyBLASTP
353968354843876hypothetical proteinBLASTP
354840355673834hypothetical proteinBLASTP
355657356427771hypothetical proteinBLASTP
356424356897474hypothetical proteinBLASTP
356881357453573hypothetical proteinBLASTP
3574783590341557hypothetical proteinBLASTP
359131359562432biopolymer transport protein ExbDQuickGO ontologyBLASTP
3595663606031038MotATolQExbB proton channel family proteinQuickGO ontologyBLASTP
3610823622931212cystathionine beta-lyaseQuickGO ontologyBLASTP
362486363148663putative DedA-family membrane proteinQuickGO ontologyBLASTP
363240364133894AraC-family regulatory proteinQuickGO ontologyBLASTP
3645313656881158aldehyde reductaseQuickGO ontologyBLASTP
365751365960210hypothetical proteinBLASTP
36610736694083425-diketo-D-gluconate reductase AQuickGO ontologyBLASTP
366962367774813hypothetical proteinBLASTP
3677593693061548hypothetical proteinBLASTP