Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:2999514 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
299817129995171347hypothetical proteinBLASTP
29995143000464951hypothetical proteinBLASTP
300048230014861005hypothetical proteinBLASTP
30014973002051555hypothetical proteinBLASTP
300212930031481020putative oxidoreductaseQuickGO ontologyBLASTP
30031593003662504hypothetical proteinBLASTP
300370930050671359putative transporter proteinQuickGO ontologyBLASTP
30051913005400210hypothetical protein
30055153006441927LysR family transcriptional regulatorQuickGO ontologyBLASTP
30069283007665738quorum-sensing transcriptional activator YpeRQuickGO ontologyBLASTP
30076583008302645N-acylhomoserine lactone synthase YpeIQuickGO ontologyBLASTP
30087333009410678hypothetical proteinBLASTP
30099383010102165hypothetical proteinBLASTP
30102893010417129hypothetical proteinBLASTP
301046130115281068putative rhodanese-related sulfurtransferaseQuickGO ontologyBLASTP
301167730127351059pheromone autoinducer 2 transporterQuickGO ontologyBLASTP
30133073013921615LuxR family regulatory proteinQuickGO ontologyBLASTP
301418830153031116N-methyltryptophan oxidaseQuickGO ontologyBLASTP
301566430168721209transposaseQuickGO ontologyBLASTP
301712330177886662-deoxyglucose-6-phosphataseQuickGO ontologyBLASTP
30181993018753555putative yfeABCD locus regulatorQuickGO ontologyBLASTP
30188283018977150hypothetical protein
30188823019757876hypothetical proteinBLASTP
30200623020955894chelated iron transport system membrane proteinQuickGO ontologyBLASTP
30209523021836885chelated iron transport system membrane proteinQuickGO ontologyBLASTP
30218363022726891ATP-binding transport proteinQuickGO ontologyBLASTP
30227233023691969periplasmic-binding proteinQuickGO ontologyBLASTP