Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:1089044 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10890441089823780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
109016810932423075hypothetical proteinBLASTP
109335110955372187hypothetical proteinBLASTP
10956521096602951hypothetical proteinBLASTP
10979671098644678putative carbonic anhydraseQuickGO ontologyBLASTP
10993871099803417hypothetical proteinBLASTP
10999731100374402general secretion pathway protein CQuickGO ontologyBLASTP
110045511023771923general secretion proteinQuickGO ontologyBLASTP
110237411038851512general secretion pathway protein EQuickGO ontologyBLASTP
110402711050731047general protein secretion proteinQuickGO ontologyBLASTP
11050931105530438general secretion pathway protein GQuickGO ontologyBLASTP
11066541107049396general secretion pathway protein JQuickGO ontologyBLASTP
11070581108014957general secretion pathway protein KQuickGO ontologyBLASTP
110799811091881191L-like GSP proteinQuickGO ontologyBLASTP
11091971109646450membrane proteinQuickGO ontologyBLASTP
11096751110514840prepilin peptidaseQuickGO ontologyBLASTP
11105661110871306putative lipoproteinQuickGO ontologyBLASTP
11111551111871717putative regulatory membrane proteinQuickGO ontologyBLASTP
111242411141151692methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
11141011114736636hypothetical proteinBLASTP
11148491115736888hypothetical proteinBLASTP
11158431116751909LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
111712011182801161putative sugar transport proteinQuickGO ontologyBLASTP
11182771119218942transcriptional activator protein LysRQuickGO ontologyBLASTP
111943311206951263diaminopimelate decarboxylaseQuickGO ontologyBLASTP
112069211217141023galactose operon repressorQuickGO ontologyBLASTP
112202411242852262putative biotin sulfoxide reductas2QuickGO ontologyBLASTP