Pre_GI Gene

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Host: NC_017063 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017063:1362000 Helicobacter pylori ELS37 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13621461362253108hypothetical protein
1362289136263935150S ribosomal protein L17QuickGO ontologyBLASTP
136263913636731035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
1363685136431162730S ribosomal protein S4QuickGO ontologyBLASTP
1364321136471639630S ribosomal protein S11QuickGO ontologyBLASTP
1364739136510136330S ribosomal protein S13QuickGO ontologyBLASTP
13651051365218114hypothetical protein
13652971365515219translation initiation factor IF-1QuickGO ontologyBLASTP
13655151366276762methionine aminopeptidaseQuickGO ontologyBLASTP
136627613675381263preprotein translocase subunit SecYQuickGO ontologyBLASTP
1367581136798240250S ribosomal protein L15QuickGO ontologyBLASTP
1368002136844544430S ribosomal protein S5QuickGO ontologyBLASTP
1368460136881635750S ribosomal protein L18QuickGO ontologyBLASTP
1368830136936653750S ribosomal protein L6QuickGO ontologyBLASTP
1369377136977239630S ribosomal protein S8QuickGO ontologyBLASTP
1369782136996718630S ribosomal protein S14QuickGO ontologyBLASTP
1369977137052254650S ribosomal protein L5QuickGO ontologyBLASTP
1370535137075622250S ribosomal protein L24QuickGO ontologyBLASTP
1370756137112436950S ribosomal protein L14QuickGO ontologyBLASTP
1371127137138726130S ribosomal protein S17QuickGO ontologyBLASTP
1371402137160220150S ribosomal protein L29QuickGO ontologyBLASTP
1371589137201442650S ribosomal protein L16QuickGO ontologyBLASTP
1372017137272170530S ribosomal protein S3QuickGO ontologyBLASTP
1372725137309336950S ribosomal protein L22QuickGO ontologyBLASTP
1373103137338428230S ribosomal protein S19QuickGO ontologyBLASTP
1373396137422683150S ribosomal protein L2QuickGO ontologyBLASTP
1374243137452428250S ribosomal protein L23QuickGO ontologyBLASTP
1374528137517564850S ribosomal protein L4QuickGO ontologyBLASTP
1375210137578557650S ribosomal protein L3QuickGO ontologyBLASTP
1375822137613631530S ribosomal protein S10QuickGO ontologyBLASTP
137634613774311086hypothetical proteinBLASTP
13776531378231579hypothetical proteinBLASTP
13782051378819615ribonuclease HIIQuickGO ontologyBLASTP
13788161379541726hypothetical proteinBLASTP
137965813814511794hypothetical proteinBLASTP
138145513828461392fumarate hydrataseQuickGO ontologyBLASTP
13830211383398378hypothetical proteinBLASTP
138340313846411239hypothetical proteinBLASTP
138463813856631026cation efflux system proteinQuickGO ontologyBLASTP