Pre_GI Gene

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Host: NC_016914 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016914:167537 Rickettsia rickettsii str. Hino chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1675371690631527endopeptidaseQuickGO ontologyBLASTP
169210169953744hypothetical proteinBLASTP
170120170494375succinate dehydrogenase cytochrome b-556 subunitQuickGO ontologyBLASTP
170639171016378succinate dehydrogenase hydrophobic membrane anchor proteinQuickGO ontologyBLASTP
1711501729401791succinate dehydrogenase flavoprotein subunitQuickGO ontologyBLASTP
173087173743657hypothetical proteinBLASTP
17390217429139030S ribosomal protein S12QuickGO ontologyBLASTP
17431817480048330S ribosomal protein S7QuickGO ontologyBLASTP
1748131769122100elongation factor GQuickGO ontologyBLASTP
17705617713176tRNA-TrpQuickGO ontology
177330177530201preprotein translocase subunit SecEQuickGO ontologyBLASTP
177546178124579transcription antitermination protein NusGQuickGO ontologyBLASTP
17839417883143850S ribosomal protein L11QuickGO ontologyBLASTP
17883717955672050S ribosomal protein L1QuickGO ontologyBLASTP
17966718017651050S ribosomal protein L10QuickGO ontologyBLASTP
18037118075138150S ribosomal protein L7L12QuickGO ontologyBLASTP
1816981858194122DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP
1860771901954119DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP