Pre_GI Gene

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Host: NC_016908 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016908:1136082 Rickettsia rickettsii str. Colombia chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
113608211371011020NADHubiquinone oxidoreductase subunit HQuickGO ontologyBLASTP
113722311392382016NADH dehydrogenase subunit GQuickGO ontologyBLASTP
11392411139597357hypothetical proteinBLASTP
113976611424022637aconitate hydrataseQuickGO ontologyBLASTP
11425841142922339F0F1 ATP synthase subunit epsilonQuickGO ontologyBLASTP
114298011444011422F0F1 ATP synthase subunit betaQuickGO ontologyBLASTP
11445741145545972F0F1 ATP synthase subunit gammaQuickGO ontologyBLASTP
114567711472091533F0F1 ATP synthase subunit alphaQuickGO ontologyBLASTP
11473751147929555F0F1 ATP synthase subunit deltaQuickGO ontologyBLASTP
114809311494721380dihydrolipoamide dehydrogenaseQuickGO ontologyBLASTP
11496271150055429ferroxidaseQuickGO ontologyBLASTP
11510141151130117hypothetical protein
11513891151691303beta-lactamase OXA-18QuickGO ontologyBLASTP
11518301152102273beta-lactamaseQuickGO ontologyBLASTP
115238111547532373multimodular transpeptidase-transglycosylase PBP 1AQuickGO ontologyBLASTP