Pre_GI Gene

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Host: NC_014560 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014560:53750 Helicobacter pylori SJM180 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
53750562182469adeninecytosine DNA methyltransferaseQuickGO ontologyBLASTP
56260577501491sodiumproline symporterQuickGO ontologyBLASTP
57777613343558Prolinepyrroline-5-carboxylate dehydrogenaseQuickGO ontologyBLASTP
6166361872210hypothetical proteinBLASTP
619856208399hypothetical protein
6249063170681hypothetical proteinBLASTP
6317164013843hypothetical proteinBLASTP
6430864490183hypothetical proteinBLASTP
6692167490570hypothetical proteinBLASTP
6750667766261hypothetical proteinBLASTP
6922669645420hypothetical proteinBLASTP
6964769997351hypothetical proteinBLASTP
7256473361798urease accessory protein UreHQuickGO ontologyBLASTP
7336173960600Urease accessory protein UreGQuickGO ontologyBLASTP
7398974753765urease accessory protein ureFQuickGO ontologyBLASTP
7476575277513urease accessory protein UreEQuickGO ontologyBLASTP
7527975866588urease accessory protein pH-dependent urea-transporterQuickGO ontologyBLASTP
76111778201710urease subunit betaQuickGO ontologyBLASTP
7782478540717urease subunit alphaQuickGO ontologyBLASTP