Pre_GI Gene

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Host: NC_014256 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014256:683384 Helicobacter pylori B8 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
683384683983600cag pathogenicity island protein SQuickGO ontologyBLASTP
684180685022843cag pathogenicity island protein TQuickGO ontologyBLASTP
685035685685651cag pathogenicity island protein UQuickGO ontologyBLASTP
686072686830759cag pathogenicity island protein VQuickGO ontologyBLASTP
6868356884331599cag pathogenicity island protein WQuickGO ontologyBLASTP
6884866900541569cag pathogenicity island protein XQuickGO ontologyBLASTP
6900696955345466cag pathogenicity island protein YQuickGO ontologyBLASTP
695683696282600cag pathogenicity island protein ZQuickGO ontologyBLASTP
696287697279993cag pathogenicity island protein alphaQuickGO ontologyBLASTP
6972886995342247cag pathogenicity island protein betaQuickGO ontologyBLASTP
699579699698120hypothetical proteinBLASTP
699618699893276hypothetical proteinBLASTP
700014700523510cag pathogenicity island protein gammaQuickGO ontologyBLASTP
7005337019781446cag pathogenicity island protein deltaQuickGO ontologyBLASTP
701971702675705cag pathogenicity island protein epsilonQuickGO ontologyBLASTP
702739703086348cag pathogenicity island protein zetaQuickGO ontologyBLASTP
703259704110852chitin synthase regulatory factor 3QuickGO ontologyBLASTP
704147704326180hypothetical protein
7043407057851446glutamine synthetaseQuickGO ontologyBLASTP
7059237079862064hypothetical proteinBLASTP
70804970849845050S ribosomal protein L9QuickGO ontologyBLASTP
708502709044543protein HslVQuickGO ontologyBLASTP
7090447103751332heat shock protein HslUQuickGO ontologyBLASTP
710375711280906GTP-binding protein EraQuickGO ontologyBLASTP
711277712269993hypothetical proteinBLASTP
712521713129609hypothetical proteinBLASTP
713090713659570hypothetical proteinBLASTP
713661714134474hypothetical proteinBLASTP
714134714679546hypothetical proteinBLASTP
715093715953861regulator of nonsense transcripts 1QuickGO ontologyBLASTP
716234716422189hypothetical proteinBLASTP
7168167203703555cytotoxin-associated protein AQuickGO ontologyBLASTP
720949721224276regulator of nonsense transcripts 1QuickGO ontologyBLASTP
721382722149768glutamate racemaseQuickGO ontologyBLASTP
7221887235041317Transcription termination factor RhoQuickGO ontologyBLASTP
72377072397320450S ribosomal protein L31QuickGO ontologyBLASTP
723998724861864hypothetical proteinBLASTP
724874725557684TrmH family RNA methyltransferaseQuickGO ontologyBLASTP
725570726535966sialidase AQuickGO ontology
726532727353822hypothetical proteinBLASTP
727450727863414hypothetical protein
728069728239171hypothetical protein
728151728258108hypothetical protein