Pre_GI Gene

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Host: NC_014256 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014256:636000 Helicobacter pylori B8 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
636012636809798vacuolating cytotoxinQuickGO ontologyBLASTP
6367796399733195vacuolating cytotoxinQuickGO ontology
6401976415941398cysteinyl-tRNA synthetaseQuickGO ontologyBLASTP
6415956430551461integral membrane protein MviNQuickGO ontologyBLASTP
6431486449921845hypothetical proteinBLASTP
645017645568552Holliday junction ATP-dependent DNA helicase RuvAQuickGO ontologyBLASTP
645872646768897hypothetical proteinBLASTP
6468596484151557hypothetical proteinBLASTP
648519648851333hypothetical proteinBLASTP
648848649840993hypothetical proteinBLASTP
6502186513541137putative conserved potassium channel proteinQuickGO ontologyBLASTP
65150465169218950S ribosomal protein L28QuickGO ontologyBLASTP
651792652628837hypothetical proteinBLASTP
6526746538161143phospho-N-acetylmuramoyl-pentapeptide- transferaseQuickGO ontologyBLASTP
6538186550861269UDP-N-acetylmuramoyl-L-alanineD-glutamate ligaseQuickGO ontologyBLASTP
655083655343261hypothetical protein
655333655734402hypothetical proteinBLASTP
6559656572931329hypothetical proteinBLASTP
6573046586321329hypothetical proteinBLASTP