Pre_GI Gene

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Host: NC_011498 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011498:553525 Helicobacter pylori P12, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5535255549701446cag pathogenicity island protein DeltaQuickGO ontologyBLASTP
554980555489510cag pathogenicity island protein GammaQuickGO ontologyBLASTP
5559635582092247cag pathogenicity island protein BetaQuickGO ontologyBLASTP
558218559210993cag pathogenicity island protein AlphaQuickGO ontologyBLASTP
559215559814600cag pathogenicity island protein ZQuickGO ontologyBLASTP
5599645656695706cag pathogenicity island protein Y VirB10-like proteinQuickGO ontologyBLASTP
5656845672521569cag pathogenicity island protein X VirB9-like proteinQuickGO ontologyBLASTP
5673055689121608cag pathogenicity island protein WQuickGO ontologyBLASTP
568917569675759cag pathogenicity island protein VQuickGO ontologyBLASTP
570070570720651cag pathogenicity island protein UQuickGO ontologyBLASTP
570733571575843cag pathogenicity island protein TQuickGO ontologyBLASTP
571777572376600cag pathogenicity island protein SQuickGO ontologyBLASTP
572815573195381cag pathogenicity island protein QQuickGO ontologyBLASTP
572903573205303cag pathogenicity island protein RQuickGO ontologyBLASTP
573621573974354cag pathogenicity island protein PQuickGO ontologyBLASTP