Pre_GI Gene

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Host: NC_011256 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011256:37617 Borrelia duttonii Ly plasmid pl70, complete sequence

Host Lineage: Borrelia duttonii; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: Borrelia duttonii Ly was isolated from a 2-year-old girl with tick-borne relapsing fever in Tanzania. Borrelia duttonii is the causative agent of tick-borne relapsing fever in east Africa. This disease is endemic in much of east Africa and is one of the top 10 diseases associated with deaths in children under the age of five. This disease is transmitted by the bite of the soft-bodied tick Ornithodoros moubata. Ticks become infected with Borrelia duttonii while feeding on an infected rodent. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the organism into a mammalian host through its infectious saliva. Humans become exposed to the infected ticks through contact with rodents or rodent nests. Relapsing fever is characterized by a period of chills, fever, headache, and malaise, an asymptomatic period, followed by another episode of symptoms. This cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
30215611260hypothetical protein
21762895720BdrQ-like proteinQuickGO ontologyBLASTP
314565343390hypothetical proteinBLASTP
3761738177561plasmid partitioning associated protein-1QuickGO ontologyBLASTP
3815338896744PF32 plasmid partition proteinQuickGO ontologyBLASTP
3893839471534PF49 plasmid partition proteinQuickGO ontologyBLASTP
4132841894567family 113-like proteinQuickGO ontology
4219143180990vlp protein delta subfamilyQuickGO ontologyBLASTP
43381444541074vlp protein beta subfamilyQuickGO ontologyBLASTP
4555646215660vsp proteinQuickGO ontologyBLASTP
46965479871023vlp protein gamma subfamilyQuickGO ontologyBLASTP
5460155206606vsp proteinQuickGO ontologyBLASTP
5607756736660vsp proteinQuickGO ontologyBLASTP
56988580191032vlp protein delta subfamilyQuickGO ontologyBLASTP
58154591641011vlp protein gamma subfamilyQuickGO ontologyBLASTP
59541606201080vlp protein beta subfamilyQuickGO ontologyBLASTP
6262863221594hypothetical proteinBLASTP
63350645461197BBK32 immunogenic protein P35 lipoproteinQuickGO ontologyBLASTP