Pre_GI Gene

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Host: NC_010729 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010729:1014957 Porphyromonas gingivalis ATCC 33277, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This strain was isolated from human gingiva. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
101495710167441788peptidase M24 familyQuickGO ontologyBLASTP
101679310183401548hypothetical proteinBLASTP
101892310208451923molecular chaperone DnaKQuickGO ontologyBLASTP
102162310228851263tyrosine type site-specific recombinaseQuickGO ontologyBLASTP
102353110246161086transposase in ISPg1QuickGO ontologyBLASTP
10250941025738645hypothetical protein
10262381026375138putative partial excisionaseQuickGO ontologyBLASTP
10264261026593168hypothetical proteinBLASTP
102660810278131206hypothetical proteinBLASTP
10280441028931888putative DNA primaseQuickGO ontologyBLASTP
10290611029423363mobilization proteinQuickGO ontologyBLASTP
10294131030354942putative mobilization proteinQuickGO ontologyBLASTP
10303801031102723hypothetical proteinBLASTP
10312321031435204hypothetical proteinBLASTP
103150710327151209hypothetical proteinBLASTP
103270510346061902hypothetical proteinBLASTP