Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:2235500 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
223690722388261920hypothetical proteinBLASTP
22388432239070228hypothetical proteinBLASTP
22391872239414228hypothetical proteinBLASTP
22394112240073663phage-related lysozymeQuickGO ontologyBLASTP
22401372240466330hypothetical proteinBLASTP
224048022445234044hypothetical proteinBLASTP
22445452244778234hypothetical proteinBLASTP
224478822459181131hypothetical proteinBLASTP
224592622469391014hypothetical proteinBLASTP
224694822479491002hypothetical proteinBLASTP
22479622248615654hypothetical proteinBLASTP
224865322508422190hypothetical proteinBLASTP
225085622521511296hypothetical proteinBLASTP
22521862253037852hypothetical proteinBLASTP
22530392253464426hypothetical proteinBLASTP
225346422549211458hypothetical proteinBLASTP
22549232255630708hypothetical proteinBLASTP