Pre_GI Gene

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Host: NC_009727 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009727:1001203 Coxiella burnetii Dugway 7E9-12, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
100120310025941392hypothetical proteinBLASTP
100315310056752523ankyrin repeat proteinQuickGO ontologyBLASTP
10060281006975948alcohol dehydrogenase zinc-containingQuickGO ontologyBLASTP
10077691008068300putative nucleotidyltransferaseQuickGO ontologyBLASTP
10086621008913252hypothetical proteinBLASTP
10091651009383219hypothetical proteinBLASTP
10094241009693270hypothetical proteinBLASTP
100995810111001143hypothetical proteinBLASTP
10112151011367153hypothetical proteinBLASTP
10116661012211546hypothetical proteinBLASTP
10126771012871195hypothetical proteinBLASTP
10132791013407129hypothetical proteinBLASTP
1013486101357388tRNA-LeuQuickGO ontology
1013620101369071tRNA-CysQuickGO ontology
10138291014086258hypothetical proteinBLASTP
10141441014905762hypothetical proteinBLASTP
101502910160931065hypothetical proteinBLASTP
101628910177011413putative dioxygenaseQuickGO ontologyBLASTP
10177521018066315hypothetical proteinBLASTP
10180631018437375crcB proteinQuickGO ontologyBLASTP
101843810197661329adenosylmethionine-8-amino-7-oxononanoate transaminaseQuickGO ontologyBLASTP
10201351021100966biotin synthaseQuickGO ontologyBLASTP
1021087102224111558-amino-7-oxononanoate synthaseQuickGO ontologyBLASTP
10222351022939705putative carboxylesterase BioHQuickGO ontologyBLASTP
10229321023675744putative biotin biosynthesis protein BioCQuickGO ontologyBLASTP
10236721024400729dethiobiotin synthaseQuickGO ontologyBLASTP
10243281025299972bifunctional protein birAQuickGO ontologyBLASTP