Pre_GI Gene

Some Help

Host: NC_009699 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009699:2056500 Clostridium botulinum F str. Langeland chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
205682220580481227stage IV sporulation protein BQuickGO ontologyBLASTP
20584702059366897homoserine O-succinyltransferaseQuickGO ontologyBLASTP
205939320606191227homoserine dehydrogenaseQuickGO ontologyBLASTP
206065920619391281O-acetylhomoserine aminocarboxypropyltransferasecysteine synthase family proteinQuickGO ontologyBLASTP
206223820639411704DNA repair protein recNQuickGO ontologyBLASTP
20639542064406453arginine repressorQuickGO ontologyBLASTP
20644082065253846ATP-NAD kinaseQuickGO ontologyBLASTP
20652532066074822hemolysin AQuickGO ontologyBLASTP
2066096206796418691-deoxy-D-xylulose-5-phosphate synthaseQuickGO ontologyBLASTP
20679652068522558hypothetical proteinBLASTP
20693252070197873geranyltranstransferaseQuickGO ontologyBLASTP
20703222070537216exodeoxyribonuclease VII small subunitQuickGO ontologyBLASTP
207063120718361206exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
20719072072338432transcription antitermination protein NusBQuickGO ontologyBLASTP
20724772072872396alkaline shock proteinQuickGO ontologyBLASTP
20729542073478525stage III sporulation protein AHQuickGO ontologyBLASTP
20735402074136597stage III sporulation protein AGQuickGO ontologyBLASTP