Pre_GI Gene

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Host: NC_009494 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009494:2477743 Legionella pneumophila str. Corby chromosome, complete genome

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Legionella pneumophila str. Corby is a human isolate. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
247774324791911449hypothetical proteinBLASTP
247936924805471179hypothetical proteinBLASTP
24806352480994360hypothetical proteinBLASTP
24812282481806579hypothetical proteinBLASTP
24818652482731867aminoglycoside 6-adenylyltransferaseQuickGO ontologyBLASTP
248286424846601797multidrug resistance ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
248494824895554608DotIcm system substrate protein SdeCQuickGO ontologyBLASTP
248976924908901122Sid related protein-like proteinQuickGO ontologyBLASTP
249094424935712628hypothetical proteinBLASTP
249384824996135766DotIcm system substrate protein SdeBQuickGO ontologyBLASTP
249999625022632268ankyrin repeat family transporter proteinQuickGO ontologyBLASTP