Pre_GI Gene

Some Help

Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:1655731 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
165573116568971167hypothetical proteinBLASTP
16569521657656705GTP cyclohydrolase IQuickGO ontologyBLASTP
165779816589491152hypothetical proteinBLASTP
16590851659954870LysR family transcriptional regulatorQuickGO ontologyBLASTP
166022816613671140alcohol dehydrogenaseQuickGO ontologyBLASTP
16613881662230843esteraseQuickGO ontologyBLASTP
166278316651432361hypothetical proteinBLASTP
166514516664071263hypothetical proteinBLASTP
16664091667077669ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
166708716683971311heme-binding proteinQuickGO ontologyBLASTP
166893216702061275molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
16702081670978771molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
16710431671696654hypothetical proteinBLASTP
167192416736871764ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
16742021674825624hypothetical proteinBLASTP
167503716764041368hypothetical proteinBLASTP
16764291676881453hypothetical proteinBLASTP
16768811677462582hypothetical proteinBLASTP
167743716785221086hypothetical proteinBLASTP
167848616802491764hypothetical proteinBLASTP