Pre_GI Gene

Some Help

Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:2905413 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
290541329066811269hypothetical proteinBLASTP
290670129077831083hypothetical proteinBLASTP
290801429102662253putative enzymeQuickGO ontologyBLASTP
2910825291090076tRNA-MetQuickGO ontologyBLASTP
29111482912014867IS3 ORF2QuickGO ontologyBLASTP
29120112912310300IS3 ORF1QuickGO ontologyBLASTP
29124292912932504IS1 ORF2QuickGO ontologyBLASTP
29130072913213207putative IS1 encoded proteinQuickGO ontologyBLASTP
291332629145491224prophage CP4-57 integraseQuickGO ontologyBLASTP
29153312915813483small protein BQuickGO ontologyBLASTP
29163272916701375hypothetical proteinBLASTP
29167632917062300small membrane protein AQuickGO ontologyBLASTP
291725329189141662DNA repair protein recNQuickGO ontologyBLASTP
29190002919878879hypothetical proteinBLASTP
29200012920594594GrpE proteinQuickGO ontologyBLASTP
292064929219111263hypothetical proteinBLASTP
29219562922822867hypothetical proteinBLASTP
292291429242751362Signal recognition particle proteinQuickGO ontologyBLASTP