Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:402599 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4025994050582460bifunctional aspartokinasehomoserine dehydrogenase IQuickGO ontologyBLASTP
405061405990930homoserine kinaseQuickGO ontologyBLASTP
4059944072831290threonine synthaseQuickGO ontologyBLASTP
408100408879780hypothetical proteinBLASTP
409369410361993transaldolase BQuickGO ontologyBLASTP
410405410563159hypothetical proteinBLASTP
410649411236588molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
4113644127521389transport proteinQuickGO ontologyBLASTP
4128224152692448hypothetical proteinBLASTP
415557416168612membrane proteinQuickGO ontologyBLASTP
4165424184521911chaperone protein DnaKQuickGO ontologyBLASTP
4185644197031140chaperone protein DnaJQuickGO ontologyBLASTP
4199464211301185sodium-proton antiporterQuickGO ontologyBLASTP
421260422159900transcriptional activator protein NhaRQuickGO ontologyBLASTP
42229042255326430S ribosomal protein S20QuickGO ontologyBLASTP
422968423906939riboflavin biosynthesis protein riboflavin kinase and FMN adenyltransferaseQuickGO ontologyBLASTP