Pre_GI Gene

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Host: NC_008149 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008149:3529428 Yersinia pestis Nepal516, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
35294283530249822pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
35305373531091555membrane proteinQuickGO ontologyBLASTP
35310883531378291hypothetical proteinBLASTP
35314783532071594hypothetical proteinBLASTP
353205235331941143oxygen-independent coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
353338435427169333virulence determinantQuickGO ontologyBLASTP
35432143543459246hypothetical proteinBLASTP
35434173543947531hypothetical proteinBLASTP
35440593544985927glutaminaseQuickGO ontologyBLASTP
35450963545422327hypothetical proteinBLASTP
35454223546141720Putative methyltransferaseQuickGO ontologyBLASTP
354647635475941119AG-specific adenine glycosylaseQuickGO ontologyBLASTP
35477723548044273hypothetical proteinBLASTP
354821535493031089membrane-bound lytic murein transglycosylase CQuickGO ontologyBLASTP
354960335507031101hypothetical proteinBLASTP
355069635528402145hydroxamate-type ferrisiderophore receptorQuickGO ontologyBLASTP
35529233553906984sugar transport system permease proteinQuickGO ontologyBLASTP
355393935554381500sugar transport ATP-binding proteinQuickGO ontologyBLASTP