Pre_GI Gene

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Host: NC_008086 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008086:513407 Helicobacter pylori HPAG1, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from a Swedish patient with chronic atrophic gastritis, the precursor to gastric adenocarcinoma. Causes peptic ulcers. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
513407514165759HP0521B-like proteinQuickGO ontologyBLASTP
5141585156031446cag pathogenicity island protein 3QuickGO ontologyBLASTP
515613516122510cag pathogenicity island protein 4QuickGO ontologyBLASTP
5162415184872247cag pathogenicity island protein 5QuickGO ontologyBLASTP
518496519488993cag pathogenicity island encoded proteinATPase proteinQuickGO ontologyBLASTP
519493520092600cag pathogenicity island protein ZQuickGO ontologyBLASTP
5202275241143888cag pathogenicity island protein YQuickGO ontologyBLASTP
5241735261611989cag pathogenicity island protein YQuickGO ontologyBLASTP
5261765277471572cag pathogenicity island protein XQuickGO ontologyBLASTP
5277975294041608cag pathogenicity island protein WQuickGO ontologyBLASTP
529409530167759cag pathogenicity island protein VQuickGO ontologyBLASTP
530565531215651cag pathogenicity island protein UQuickGO ontologyBLASTP
531228532070843cag pathogenicity island protein TQuickGO ontologyBLASTP
53218853227790hypothetical proteinBLASTP
532270532869600cag pathogenicity island protein SQuickGO ontologyBLASTP
533301533681381cag pathogenicity island protein QQuickGO ontologyBLASTP
5348825360121131cag pathogenicity island protein MQuickGO ontologyBLASTP
536027536947921cag pathogenicity island protein NQuickGO ontologyBLASTP
537029537742714cag pathogenicity island protein LQuickGO ontologyBLASTP
5377395388841146cag pathogenicity island protein IQuickGO ontologyBLASTP